| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Cannabidiol | 📋 | ✍ | ⛔ | | 38649735 | Cannabidiol - an effective analgesic for toothache? |
| Curcumin | 📋 | ✍ | ⛔ | | 38266637 | Effect of Curcumin on Dysmenorrhea and Symptoms of Premenstrual Syndrome: A Systematic Review and Meta-Analysis |
| Melatonin | 📋 | ✍ | ⛔ | | 37978917 | Melatonin Relieves Paclitaxel-Induced Neuropathic Pain by Regulating pNEK2-Dependent Epigenetic Pathways in DRG Neurons |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38613122 | Vitamin D Supplementation for Patients with Dysmenorrhoea: A Meta-Analysis with Trial Sequential Analysis of Randomised Controlled Trials |
| Magnesium | 📋 | ✍ | ⛔ | | 38204302 | Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 37494903 | The Use of Lavender Aromatherapy for Pain After Total Hip and Total Knee Arthroplasty: A Randomized Trial |
| Vitamin C | 📋 | ✍ | ⛔ | | 38644802 | Dietary vitamin C intake and changes in frequency, severity, and location of pain in older adults |
| Capsaicin | 📋 | ✍ | ⛔ | | 38344267 | Topical capsaicin 8% patch in peripheral neuropathic pain: Efficacy and quality of life |
| Ginger | 📋 | ✍ | ⛔ | | 36978993 | Ginger ( Zingiber officinale) Root Capsules Enhance Analgesic and Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation |
| Resveratrol | 📋 | ✍ | ⛔ | | 38138300 | Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial |
| CoQ10 | 📋 | ✍ | ⛔ | | 38204302 | Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 38138300 | Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 36199624 | Evaluation of serum vitamin B12 levels and its correlation with clinical presentation in patients with trigeminal neuralgia |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 37686880 | Efficacy of Boswellia serrata Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial |
| PEA | 📋 | ✍ | ⛔ | | 38533175 | The Comparative Efficacy of Palmitoylethanolamide (PEA) With the Combination of Pregabalin and Nortriptyline on Post-extraction Trigeminal Neuropathy by Using Magnetic Resonance (MR) Neurography: A Randomized Clinical Trial |
| Frankincense | 📋 | ✍ | ⛔ | | 37686880 | Efficacy of Boswellia serrata Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial |
| Quercetin | 📋 | ✍ | ⛔ | | 38588462 | Use of kersetin and fisetin flavonoids in combination with pregabalin and gabapentin in the treatment of neuropathic pain |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 38138300 | Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial |
| Micronutrients | 📋 | | ⛔ | | 38307641 | Nutraceuticals in migraine |
| Saw Palmetto | 📋 | ✍ | ⛔ | | 33452912 | The efficacy and safety of Serenoa repens extract for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome: a multicenter, randomized, double-blind, placebo-controlled trial |
| Berberine | 📋 | ✍ | ⛔ | | 38061440 | Oral treatment with Berberine reduces peripheral nociception: Possible interaction with different nociceptive pathways activated by different allogeneic substances |
| Medicinal Plants | 📋 | | | | 37576742 | Comparative evaluation of the potential anti-spasmodic activity of Piper longum, Piper nigrum, Terminalia bellerica, Terminalia chebula, and Zingiber officinale in experimental animals |
| Vitamin E | 📋 | ✍ | ⛔ | | 38021953 | Psychological Assessment and Treatment Effectiveness in Mastalgia: Developing a Treatment Algorithm |
| Bromelain | 📋 | ✍ | ⛔ | | 38075000 | Bromelain regulates TRP channels to induce orofacial nociception relief in adult zebrafish |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 38204302 | Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study |
| Myrrh | 📋 | ✍ | ⛔ | | 38186647 | An aqueous Commiphora myrrha extract ameliorates paclitaxel-induced peripheral neuropathic pain in mice |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 37730471 | Randomized Trial Examining Efficacy of Mentha piperita in Reducing Chronic Headache Discomfort in Youth |
| Puerarin | 📋 | ✍ | ⛔ | | 38516772 | Puerarin attenuates remifentanil‑induced postoperative hyperalgesia via targeting PAX6 to regulate the transcription of TRPV1 |
| Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 35214045 | Preclinical Characterization of Antinociceptive Effect of Bergamot Essential Oil and of Its Fractions for Rational Translation in Complementary Therapy |
| Essential Oils | 📋 | | ⛔ | | 37899272 | Essential Oils as an Alternative Treatment for Migraine Headache: A Systematic Review and Meta-Analysis |
| Naringenin | 📋 | ✍ | ⛔ | | 38715438 | Naringenin relieves paclitaxel-induced pain by suppressing calcitonin gene-related peptide signalling and enhances the anti-tumour action of paclitaxel |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 38042023 | Vitamin B6 and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004 |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 38021953 | Psychological Assessment and Treatment Effectiveness in Mastalgia: Developing a Treatment Algorithm |
| Linalool | 📋 | | ⛔ | | 38243945 | An In Silico Approach to Exploring the Antinociceptive Biological Activities of Linalool and its Metabolites |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 36034087 | Anti-nociceptive effect of black seed oil on an animal model of chronic constriction injury |
| Turmeric | 📋 | ✍ | ⛔ | | 37937613 | In vivo efficacy of turmeric (Curcuma longa L.) in the treatment of peripheral neuropathy: A systematic review of animal models |
| Crocin | 📋 | ✍ | ⛔ | | 34390797 | Effectiveness of crocin of saffron (Crocus sativus L.) against chemotherapy-induced peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial |
| EGCG | 📋 | ✍ | ⛔ | | 37257804 | Suppression of the excitability of rat nociceptive secondary sensory neurons following local administration of the Phytochemical, (-)-Epigallocatechin-3-gallate |
| Emodin | 📋 | | ⛔ | | 38144917 | Emodin inhibits HDAC6 mediated NLRP3 signaling and relieves chronic inflammatory pain in mice |
| Ginsenosides | 📋 | ✍ | ⛔ | | 36368461 | Ginsenoside Rb1, a principal effective ingredient of Panax notoginseng, produces pain antihypersensitivity by spinal microglial dynorphin A expression |
| Pine Bark | 📋 | ✍ | ⛔ | | 37314422 | Variation of inflammatory indexes in patients with chronic abacterial prostatitis treated with an herbal compound/extract |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 38042023 | Vitamin B6 and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004 |
| Caffeine | 📋 | ✍ | ⛔ | | 37513588 | Caffeine for Headaches: Helpful or Harmful? A Brief Review of the Literature |
| Citicoline | 📋 | ✍ | ⛔ | | 36317853 | Dexamethasone and Citicoline Mitigate Cisplatin-Induced Peripheral Neuropathy: A Novel Experimental Study in Mice |
| Diosmin | 📋 | ✍ | ⛔ | | 34486275 | [Protection of the prostate in conditions of chronic pelvis varicose] |
| Ginseng | 📋 | ✍ | ⛔ | | 35264958 | Progress on the Elucidation of the Antinociceptive Effect of Ginseng and Ginsenosides in Chronic Pain |
| Lycopene | 📋 | ✍ | ⛔ | | 37839004 | [Lycopene for the treatment of chronic prostatitis / chronic pelvic pain syndrome: Effect and mechanism based on network pharmacology and molecular docking] |
| Metformin | 📋 | ✍ | ⛔ | | 38287855 | Metformin Alleviates Pain States by Regulating the Balance of Spinal Synaptic Transmission |
| Probiotics | 📋 | ✍ | ⛔ | | 38077171 | Evaluating the Effects of Probiotic Supplementation on Neuropathic Pain and Oxidative Stress Factors in an Animal Model of Chronic Constriction Injury of the Sciatic Nerve |
| Selenium | 📋 | ✍ | ⛔ | | 37306592 | Investigation of the effect of oral selenium on the reduction of clinical symptoms and joint pain in patients with rheumatoid arthritis in the Iranian population |
| Valerian Root | 📋 | ✍ | ⛔ | | 35082982 | The effects of Valerian on sleep spindles in a model of neuropathic pain |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 36047917 | Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey |
| Astaxanthin | 📋 | ✍ | ⛔ | | 38056144 | Astaxanthin alleviates chronic prostatitis/chronic pelvic pain syndrome by increasing colonization of Akkermansia muciniphila in the intestine |
| Baicalin | 📋 | ✍ | ⛔ | | 34815689 | Transcriptome Sequencing Explores the Mechanism of Baicalin on Bone Cancer Pain |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 38110000 | Efficacy of high dosage anti-inflammatory EPA/DHA for migraine prophylaxis: a network meta-analysis |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 36811684 | Synergistic effect of ellagic acid and gabapentin in a rat model of neuropathic pain |
| Fisetin | 📋 | ✍ | ⛔ | | 38588462 | Use of kersetin and fisetin flavonoids in combination with pregabalin and gabapentin in the treatment of neuropathic pain |
| Fish Oil | 📋 | ✍ | ⛔ | | 34275822 | Comparative antioxidant and analgesic effect of sesame oil, fish oil and their combination in experimental animal model |
| Food | 📋 | | | | 38068855 | The Ketogenic Diet in the Prevention of Migraines in the Elderly |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 38718890 | Efficacy and Safety of Ginkgo biloba Extract in the Treatment of Unstable Angina Pectoris: A Systematic Review and Network Meta-Analysis |
| L-Carnitine | 📋 | ✍ | ⛔ | | 33899209 | Comparing effects of L-carnitine and sildenafil citrate on histopathologic recovery from sciatic nerve crush injury in female albino rats |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 35068061 | Men suffering from category III chronic prostatitis may benefit from N-acetylcysteine as an adjunct to alpha-blockers |
| Naringin | 📋 | ✍ | ⛔ | | 35670529 | Protective effect of naringin against oxaliplatin-induced peripheral neuropathy in rats: A behavioral and molecular study |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 37314422 | Variation of inflammatory indexes in patients with chronic abacterial prostatitis treated with an herbal compound/extract |
| Vitamin B Complex | 📋 | | ⛔ | | 38011468 | B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 38499208 | A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine |
| Escin | 📋 | ✍ | ⛔ | | 37876856 | Deciphering the Molecular Mechanism of Escin against Neuropathic Pain: A Network Pharmacology Study |
| Genistein | 📋 | ✍ | ⛔ | | 35837770 | Genistein attenuates LPS - induced inflammatory injury of rat dorsal root ganglion neuron via down - regulating HDAC6 |
| Gotu Kola | 📋 | ✍ | ⛔ | | 38198371 | Standardized Centella asiatica extract ECa 233 alleviates pain hypersensitivity by modulating P2X3 in trigeminal neuropathic pain |
| Luteolin | 📋 | ✍ | ⛔ | | 37478667 | Potential anxiolytic and antidepressant-like effects of luteolin in a chronic constriction injury rat model of neuropathic pain: Role of oxidative stress, neurotrophins, and inflammatory factors |
| MSM | 📋 | ✍ | ⛔ | | 37447322 | Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial |
| Olive Oil | 📋 | ✍ | ⛔ | | 38306883 | Daily olive oil intake is feasible to reduce trigeminal neuralgia facial pain: A pilot study |
| Paeoniflorin | 📋 | | | | 36707182 | Repeated topical paeoniflorin attenuates postoperative pain and accelerates cutaneous fibroblast proliferation in mice |
| Phytochemicals | 📋 | | | | 38519585 | The predictive role of the dietary phytochemical index in relation to the clinical and psychological traits of migraine headaches |
| Saffron | 📋 | ✍ | ⛔ | | 33105854 | Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice |
| Toothache Plant | 📋 | | | | 35843412 | Evaluation of the in vitro and in vivo anti-inflammatory activity of Gymnosporia montana (Roth). Benth leaves |
| Zinc | 📋 | ✍ | ⛔ | | 37165643 | Efficacy of zinc supplementation for the treatment of dysmenorrhoea: a double-blind randomised controlled trial |
| 5-HTP | 📋 | ✍ | ⛔ | | 10849040 | L-5-Hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo-controlled study. For the Portuguese Head Society |
| Apigenin | 📋 | ✍ | ⛔ | | 37258427 | Apigenin Alleviates Allodynia and Hyperalgesia in a Mouse Model of Chemotherapy-Induced Peripheral Neuropathy via Regulating Microglia Activation and Polarization |
| Ashwagandha | 📋 | ✍ | ⛔ | | 34836854 | Antipyretic and antinociceptive potential of Ricinus communis L. and Withania somnifera L. hydroalcoholic extracts in Wistar rats: A comparative study |
| Bee Venom | 📋 | ✍ | ⛔ | | 36828443 | Bee Venom Acupuncture for Neck Pain: A Review of the Korean Literature |
| Calcium | 📋 | ✍ | ⛔ | | 38406773 | The effects of vitamin D and calcium on primary dysmenorrhea: a systematic review |
| Chondroitin | 📋 | ✍ | ⛔ | | 37377986 | Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia |
| Collagen | 📋 | ✍ | | | 37551682 | Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults |
| Fennel | 📋 | ✍ | ⛔ | | 34187122 | Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis |
| Fucoidan | 📋 | ✍ | ⛔ | | 28035379 | Antinociceptive effects of fucoidan in rat models of vincristine-induced neuropathic pain |
| Gingerol | 📋 | ✍ | | | 36079679 | The Effect of Ginger and Its Sub-Components on Pain |
| Hesperidin | 📋 | ✍ | ⛔ | | 34743946 | The protective effects of hesperidin against paclitaxel-induced peripheral neuropathy in rats |
| Lemon Balm | 📋 | ✍ | ⛔ | | 31011354 | The Effects of Lemon balm on Menstrual Bleeding and the Systemic Manifestation of Dysmenorrhea |
| Licorice Root | 📋 | ✍ | ⛔ | | 34349979 | Liquorice for pain? |
| Mangiferin | 📋 | | ⛔ | | 30333751 | Anti-allodynic Effect of Mangiferin in Rats With Chronic Post-ischemia Pain: A Model of Complex Regional Pain Syndrome Type I |
| Peony | 📋 | | ⛔ | | 38139073 | Peony Pollen Protects against Primary Dysmenorrhea in Mice by Inhibiting Inflammatory Response and Regulating the COX2/PGE2 Pathway |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 34576905 | Antinociceptive Synergism of Pomegranate Peel Extract and Acetylsalicylic Acid in an Animal Pain Model |
| Thymoquinone | 📋 | | ⛔ | | 37813830 | Thymoquinone Alleviates Paclitaxel-Induced Peripheral Neuropathy through Regulation of the TLR4-MyD88 Inflammatory Pathway |
| Angelica | 📋 | ✍ | ⛔ | | 35555968 | Assessing the Antinociceptive Effects and Tolerance Development of Decursinol in Nociceptive, Inflammatory, and Neuropathic Pain |
| Baicalein | 📋 | ✍ | ⛔ | | 35527292 | Neuroprotective Effect of Baicalein Against Oxaliplatin-Induced Peripheral Neuropathy: Impact on Oxidative Stress, Neuro-inflammation and WNT/β-Catenin Signaling |
| Bergamot | 📋 | ✍ | ⛔ | | 34681199 | The Protective Effect of Bergamot Polyphenolic Fraction (BPF) on Chemotherapy-Induced Neuropathic Pain |
| Chamomile | 📋 | ✍ | ⛔ | | 34222539 | The Effect of Chamomile on Pain and Menstrual Bleeding in Primary Dysmenorrhea: A Systematic Review |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 37123948 | Effect of chamomile aromatherapy with and without oxygen on pain of women in post cesarean section with spinal anesthesia: A randomized clinical trial |
| Cinnamon | 📋 | ✍ | ⛔ | | 32638445 | Effect of Cinnamon on Migraine Attacks and Inflammatory Markers: A Randomized Double-Blind Placebo-Controlled Trial |
| Citral | 📋 | | | | 37244090 | Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats |
| Cryptotanshinone | 📋 | | | | 33825401 | Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 38145175 | Ferulic acid via attenuation of oxidative stress and neuro-immune response utilizes antinociceptive effect in mouse model of formalin test |
| Feverfew | 📋 | ✍ | ⛔ | | 38204302 | Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study |
| Frankincense Essential Oil | 📋 | | ⛔ | | 37783585 | The effect of back massage with frankincense and myrrh oil before the cardiac electrophysiological procedure on back pain intensity and comfort: A single-blind randomized controlled trial |
| Gallic Acid | 📋 | | ⛔ | | 35682841 | Gallic Acid Alleviates Visceral Pain and Depression via Inhibition of P2X7 Receptor |
| Ginger extract | 📋 | ✍ | ⛔ | | 35733629 | Promising Health Benefits of Adjuvant Acmella and Zingiber Extracts Combined with Coenzyme Q10 Phytosomes, Supplementation in Chronic Pain Treated with Medical Cannabis: A Prospective and Open-Label Clinical Study |
| Ginkgolides | 📋 | | | | 23695070 | The efficacy of ginkgolide B in the acute treatment of migraine aura: an open preliminary trial |
| Glucosamine | 📋 | ✍ | ⛔ | | 37377986 | Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 38716504 | Grape seed-derived procyanidins decreases neuropathic pain and nerve regeneration by suppression of TLR4-Myd88 signaling |
| Hemp Oil | 📋 | ✍ | ⛔ | | 33722712 | Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain |
| Holy Basil | 📋 | ✍ | ⛔ | | 26109769 | Pharmacological and Phytochemical Evaluation of Ocimum Sanctum Root Extracts for Its Antiinflammatory, Analgesic and Antipyretic Activities |
| L-Arginine | 📋 | ✍ | ⛔ | | 34302129 | Attenuation of chronic tension headache frequency and severity with daily L-arginine and aged garlic extract dietary supplementation |
| L-Theanine | 📋 | ✍ | ⛔ | | 37984410 | Effect of theanine on the hyperexcitability of trigeminal secondary nociceptive neurons following orofacial inflammation in rats |
| Magnolol | 📋 | | | | 36414090 | Anti-nociceptive effects of magnolol via inhibition of TRPV1/P2Y and TLR4/NF-κB signaling in a postoperative pain model |
| Marjoram Essential Oil | 📋 | | ⛔ | | 30205180 | Myorelaxant Activity of essential oil from Origanum majorana L. on rat and rabbit |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 28216196 | Hypericum Perforatum (St John's Wort) Beyond Depression: A Therapeutic Perspective for Pain Conditions |
| Tanshinone | 📋 | | | | 38552937 | Sodium tanshinone IIA sulfonate suppresses microglia polarization and neuroinflammation possibly via regulating miR-125b-5p/STAT3 axis to ameliorate neuropathic pain |
| Andrographolide | 📋 | | | | 37979090 | Andrographolide inhibits the activation of spinal microglia and ameliorates mechanical allodynia |
| Astragalosides | 📋 | ✍ | ⛔ | | 36577153 | Tetramethylpyrazine and Astragaloside IV have synergistic effects against spinal cord injury-induced neuropathic pain via the OIP5-AS1/miR-34a/Sirt1/NF-κB axis |
| Bee Propolis | 📋 | ✍ | ⛔ | | 35509480 | Boswellia resin extract and propolis derived polyphenols in patients with type III chronic prostatitis/chronic pelvic pain syndrome: An Italian prospective multicenter study |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 38041701 | β-Sitosterol Alleviates Neuropathic Pain by Affect Microglia Polarization through Inhibiting TLR4/NF-κB Signaling Pathway |
| Betaine | 📋 | ✍ | ⛔ | | 38145759 | Betaine eliminates CFA-induced depressive-like behaviour in mice may be through inhibition of microglia and astrocyte activation and polarization |
| Carnosic Acid | 📋 | | | | 31316381 | Efficacy of a Combination of N-Palmitoylethanolamide, Beta-Caryophyllene, Carnosic Acid, and Myrrh Extract on Chronic Neuropathic Pain: A Preclinical Study |
| Carvacrol | 📋 | ✍ | ⛔ | | 36723608 | Pharmacological evaluation of carvacrol anti-migraine potential |
| Cat's Claw | 📋 | ✍ | ⛔ | | 35174562 | Dermo-cosmetic spray containing Rhealba oat plantlets and Uncaria tomentosa extract in patients with mild-to-moderate cutaneous pain |
| Catechins | 📋 | | | | 38159197 | (+)-Catechin Alleviates CCI-Induced Neuropathic Pain in Rats by Modulating the IL34/CSFIR Axis and Attenuating the Schwann Cell-Macrophage Cascade Response in the DRG |
| Chrysin | 📋 | ✍ | ⛔ | | 33088742 | Effect of Chrysin on Mechanical Hyperalgesia in Chronic Constriction Injury-Induced Neuropathic Pain in Rat Model |
| Clary Sage Essential Oil | 📋 | ✍ | ⛔ | | 32575103 | Effectiveness of Aromatherapy for Relief of Pain, Nausea, and Vomiting after Percutaneous Nephrolithotomy: A Randomized Controlled Trial |
| Clove | 📋 | | ⛔ | | 34804185 | Synergistic Herb-Herb Interaction of the Antinociceptive and Anti-Inflammatory Effects of Syzygium aromaticum and Rosmarinus officinalis Combination |
| Coconut | 📋 | | ⛔ | | 31350628 | Phenolic rich Cocos nucifera inflorescence extract ameliorates inflammatory responses in LPS-stimulated RAW264.7 macrophages and toxin-induced murine models |
| Coriander | 📋 | | ⛔ | | 29864950 | Antinociceptive and anti-edema properties of the ethyl acetate fraction obtained from extracts of Coriandrum sativum Linn. leaves |
| Crocetin | 📋 | | | | 33133459 | Central H 2 histaminergic and alpha-2 adrenergic receptors involvement in crocetin-induced antinociception in orofacial formalin pain in rats |
| Dihydroartemisinin | 📋 | | | | 38014931 | Dihydroartemisinin ameliorated the inflammatory response and regulated miRNA-mRNA expression profile of chronic nonbacterial prostatitis |
| Diosmetin | 📋 | | | | 38662182 | Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice |
| Echinacea | 📋 | ✍ | ⛔ | | 36578266 | Echinacea purpurea against neuropathic pain: Alkamides versus polyphenols efficacy |
| Flavonoids | 📋 | | ⛔ | | 33961144 | Flavonoids in the Treatment of Neuropathic Pain |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 37174648 | Glycyrrhizic Acid Prevents Paclitaxel-Induced Neuropathy via Inhibition of OATP-Mediated Neuronal Uptake |
| Icariin | 📋 | ✍ | | | 33822115 | Icariin ameliorates partial sciatic nerve ligation induced neuropathic pain in rats: an evidence of in silico and in vivo studies |
| Indian Gooseberry | 📋 | | ⛔ | | 31987536 | Phonophoresis of Phyllanthus amarus nanoparticle gel improves functional capacity in individuals with knee osteoarthritis: A randomized controlled trial |
| Kiwifruit | 📋 | ✍ | ⛔ | | 34275825 | Preclinical assessment of analgesic, anti-inflammatory and antipyretic potential of Fragaria ananassa and Actinidia deliciosa fruit extract |
| Ligustilide | 📋 | | | | 29200725 | Ligustilide Relieves Complete Freund's Adjuvant-induced Mechanical Hyperalgesia through Inhibiting the Activation of Spinal c-Jun N-terminal Kinase/c-Jun Pathway in Rats |
| Maca Root | 📋 | ✍ | ⛔ | | 33320645 | N-Benzyl-linoleamide, a Constituent of Lepidium meyenii (Maca), Is an Orally Bioavailable Soluble Epoxide Hydrolase Inhibitor That Alleviates Inflammatory Pain |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 35875690 | Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation |
| Paeonol | 📋 | | | | 37032648 | Paeonol alleviates neuropathic pain by modulating microglial M1 and M2 polarization via the RhoA/p38MAPK signaling pathway |
| Pectin | 📋 | ✍ | ⛔ | | 33618606 | Neuroprotective validation of pectin in T2DM-induced allodynia and hyperalgesia in diabetic peripheral neuropathic pain |
| Persimmon | 📋 | | ⛔ | | 36895410 | In-vitro antioxidant, lipoxygenase inhibitory, and in-vivo muscle relaxant potential of the extract and constituent isolated from Diospyros kaki (Japanese Persimmon) |
| Punicalagin | 📋 | ✍ | ⛔ | | 34643876 | Analgesic potency of intrathecally administered punicalagin in rat neuropathic and inflammatory pain models |
| Red Sage | 📋 | ✍ | ⛔ | | 36263128 | Efficacy and safety of eight types Salvia miltiorrhiza injections in the treatment of unstable angina pectoris: A network meta-analysis |
| Rosemary | 📋 | ✍ | ⛔ | | 34804185 | Synergistic Herb-Herb Interaction of the Antinociceptive and Anti-Inflammatory Effects of Syzygium aromaticum and Rosmarinus officinalis Combination |
| Rosmarinic Acid | 📋 | ✍ | | | 35884774 | Rosmarinic Acid Reduces Microglia Senescence: A Novel Therapeutic Approach for the Management of Neuropathic Pain Symptoms |
| Sesame Oil | 📋 | | ⛔ | | 34275822 | Comparative antioxidant and analgesic effect of sesame oil, fish oil and their combination in experimental animal model |
| Stigmasterol | 📋 | | | | 38572785 | Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R |
| Thyme | 📋 | ✍ | ⛔ | | 33117031 | Thyme Tea and Primary Dysmenorrhea Among Young Female Students |
| Thyme Essential Oil | 📋 | | ⛔ | | 34597655 | Thymus persicus (Ronniger ex Rech. f.) Jalas alleviates nociceptive and neuropathic pain behavior in mice: Multiple mechanisms of action |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 37805264 | Study of the anti-inflammatory properties of a thick extract of Tribulus terrestris L |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 38570065 | Ursolic acid molecules dock MAPK1 to modulate gut microbiota diversity to reduce neuropathic pain |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 33330853 | Statins combined with niacin reduce the risk of peripheral neuropathy |
| Vitexin | 📋 | | | | 37406508 | Vitexin inhibits pain and itch behavior via modulating TRPV4 activity in mice |
| Acacetin | 📋 | | | | 25407486 | Antipyretic and antinociceptive potential of extract/fractions of Potentilla evestita and its isolated compound, acacetin |
| Aloe Vera | 📋 | ✍ | ⛔ | | 37938932 | Isolation, preparation and investigation of leaf extracts of Aloe barbadensis for its remedial effects on tumor necrosis factor alpha (TNF-α) and interleukin (IL-6) by in vivo and in silico approaches in experimental rats |
| Andrographis | 📋 | ✍ | ⛔ | | 34532749 | Combination of Activating Blood Circulation and Detoxifying Chinese Medicines Played an Anti-Inflammatory Role in Unstable Angina Patients after Percutaneous Coronary Intervention: A Multicenter, Open-Labeled, Randomized Controlled Trial |
| Anise | 📋 | ✍ | ⛔ | | 19720342 | The Effect of an Iranian Herbal Drug on Primary Dysmenorrhea: A Clinical Controlled Trial |
| Antioxidants | 📋 | | ⛔ | | 35566585 | Effects of Antioxidants on Pain Perception in Patients with Fibromyalgia-A Systematic Review |
| Arnica | 📋 | ✍ | ⛔ | | 34677487 | Clinical Trials, Potential Mechanisms, and Adverse Effects of Arnica as an Adjunct Medication for Pain Management |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 34817757 | Bacopa monnieri attenuates glutamate-induced nociception and brain mitochondrial toxicity in Zebrafish |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 32155616 | The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study |
| Bay Leaf | 📋 | | ⛔ | | 38053830 | Aqueous extract of Laurus nobilis leaf accelerates the alcohol metabolism and prevents liver damage in single-ethanol binge rats |
| Bee Pollen | 📋 | ✍ | ⛔ | | 37486857 | Rapeseed Bee Pollen Alleviates Chronic Non-bacterial Prostatitis via Regulating Gut Microbiota |
| Beets | 📋 | ✍ | ⛔ | | 37313053 | Effect of Beta vulgaris extracts on dysmenorrhea among adolescent girls |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 29623934 | Acetyl-11-keto-β-boswellic acid extracted from Boswellia serrata promotes Schwann cell proliferation and sciatic nerve function recovery |
| Butyrate | 📋 | | ⛔ | | 38444115 | Sodium butyrate alleviates experimental autoimmune prostatitis by inhibiting oxidative stress and NLRP3 inflammasome activation via the Nrf2/HO-1 pathway |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 31341489 | Salvia officinalis, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice |
| Camphor | 📋 | ✍ | ⛔ | | 36925623 | Camphor Attenuates Hyperalgesia in Neuropathic Pain Models in Mice |
| Cherry | 📋 | | ⛔ | | 34275765 | Effect of Tart Cherry on Aromatase Inhibitor-Induced Arthralgia (AIA) in Nonmetastatic Hormone-Positive Breast Cancer Patients: A Randomized Double-Blind Placebo-Controlled Trial |
| Chlorella | 📋 | ✍ | ⛔ | | 30205315 | Effect of chlorella supplementation on systematic symptoms and serum levels of prostaglandins, inflammatory and oxidative markers in women with primary dysmenorrhea |
| Choline | 📋 | ✍ | ⛔ | | 36639747 | Inhibition effect of choline and parecoxib sodium on chronic constriction nerve injury-induced neuropathic pain in rats |
| Cinnamaldehyde | 📋 | | | | 32392570 | Cinnamaldehyde Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats |
| Cinnamon Essential Oil | 📋 | ✍ | ⛔ | | 28532683 | The essential oil from the twigs of Cinnamomum cassia Presl inhibits oxytocin-induced uterine contraction in vitro and in vivo |
| Cranberry | 📋 | ✍ | ⛔ | | 31527377 | The Use of a Combination of Vaccinium Macracarpon, Lycium barbarum L. and Probiotics (Bifiprost®) for the Prevention of Chronic Bacterial Prostatitis: A Double-Blind Randomized Study |
| D-Limonene | 📋 | ✍ | ⛔ | | 35214045 | Preclinical Characterization of Antinociceptive Effect of Bergamot Essential Oil and of Its Fractions for Rational Translation in Complementary Therapy |
| Daidzein | 📋 | ✍ | ⛔ | | 37145202 | Daidzein attenuated paclitaxel-induced neuropathic pain via the down-regulation of TRPV1/P2Y and up-regulation of Nrf2/HO-1 signaling |
| DHEA | 📋 | ✍ | ⛔ | | 37648450 | Dehydroepiandrosterone sulfate (DHEAS) is an endogenous Kv7 channel modulator that reduces Kv7/M-current suppression and inflammatory pains |
| Diallyl Disulfide | 📋 | | | | 34356307 | The Anxiolytic and Antidepressant Effects of Diallyl Disulfide and GYY4137 in Animals with Chronic Neuropathic Pain |
| Diosgenin | 📋 | | | | 36555495 | Diosgenin Exerts Analgesic Effects by Antagonizing the Selective Inhibition of Transient Receptor Potential Vanilloid 1 in a Mouse Model of Neuropathic Pain |
| Eucalyptus Essential Oil | 📋 | | ⛔ | | 31091506 | Analgesic effects of eucalyptus essential oil in mice |
| Eugenol | 📋 | | | | 38681628 | Study on mechanism of transdermal administration of eugenol for pain treatment by network pharmacology and molecular docking technology |
| Fenugreek | 📋 | ✍ | ⛔ | | 30721143 | Fenugreek Dermal Patch, a New Natural Topical Antinociceptive Medication for Relieving the Postherniotomy Pain, a Double-Blind Placebo Controlled Trial |
| Fiber | 📋 | ✍ | ⛔ | | 36687687 | The association between dietary fiber intake and severe headaches or migraine in US adults |
| Fig | 📋 | | ⛔ | | 34451731 | Himalayan Ficus palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors |
| Flaxseed | 📋 | ✍ | ⛔ | | 32664057 | Efficacy of high-dissolution turmeric-sesame formulation for pain relief in adult subjects with acute musculoskeletal pain compared to acetaminophen: A randomized controlled study |
| Folate | 📋 | ✍ | ⛔ | | 37337781 | Association between dietary folate intake and severe headache among adults in the United States: A cross-sectional survey |
| Formononetin | 📋 | | | | 30961625 | Anxiolytic effects of Formononetin in an inflammatory pain mouse model |
| Galangal | 📋 | ✍ | ⛔ | | 27633303 | Effect of Alpinia officinarum Hance alcohol extracts on primary dysmenorrheal |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 19887043 | The Use of Alpha-Lipoic Acid (ALA), Gamma Linolenic Acid (GLA) and Rehabilitation in the Treatment of Back Pain: Effect on Health-Related Quality of Life |
| Garlic | 📋 | ✍ | ⛔ | | 35263014 | The antinociceptive effect of garlic, garlic preparations, and derivative compounds |
| Geraniol | 📋 | | | | 35144136 | Geraniol enhances inhibitory inputs to the paraventricular thalamic nucleus and induces sedation in mice |
| Ginger Essential Oil | 📋 | ✍ | | | 31144450 | Effects of aromatherapy massage on pain, functional state, and quality of life in an elderly individual with knee osteoarthritis |
| Glabridin | 📋 | | | | 37239211 | Glabridin Therapy Reduces Chronic Allodynia, Spinal Microgliosis, and Dendritic Spine Generation by Inhibiting Fractalkine-CX3CR1 Signaling in a Mouse Model of Tibial Fractures |
| Green Tea | 📋 | ✍ | ⛔ | | 33372878 | The potential role of green tea and its main constituent (Epigallocatechin - 3-Gallate) in pain relief: A mechanistic review |
| Honey | 📋 | ✍ | ⛔ | | 35221265 | Enhanced antinociceptive activity of Nigella sativa oil after its combined treatment with honey in rats |
| Horsetail Grass | 📋 | ✍ | ⛔ | | 36982577 | Novel Approach to the Treatment of Neuropathic Pain Using a Combination with Palmitoylethanolamide and Equisetum arvense L. in an In Vitro Study |
| Hyaluronic Acid | 📋 | ✍ | ⛔ | | 33781014 | The efficacy and tollerability of pollen extract in combination with hyaluronic acid and vitamins in the management of patients affected by chronic prostatitis/chronic pelvic pain syndrome: a 26 weeks, randomized, controlled, single-blinded, phase III study |
| Hydroxytyrosol | 📋 | | | | 36388163 | Hydroxytyrosol Ameliorates Intervertebral Disc Degeneration and Neuropathic Pain by Reducing Oxidative Stress and Inflammation |
| Isoflavones | 📋 | ✍ | ⛔ | | 35334883 | The Inverse Correlation of Isoflavone Dietary Intake and Headache in Peri- and Post-Menopausal Women |
| Isoliquiritigenin | 📋 | | | | 38493580 | Isoliquiritigenin reduces experimental autoimmune prostatitis by facilitating Nrf2 activation and suppressing the NLRP3 inflammasome pathway |
| Knotweed | 📋 | ✍ | ⛔ | | 37876500 | Polygonum Cuspidatum Alcohol Extract Exerts Analgesic Effects via the MAPK/ERK Signaling Pathway |
| L-Carnosine | 📋 | ✍ | ⛔ | | 35768982 | Synergistic interaction between acetaminophen and L-carnosine improved neuropathic pain via NF-κB pathway and antioxidant properties in chronic constriction injury model |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 11133261 | Hypothesized Treatment for Migraines Using Low Doses of Tryptophan, Niacin, Calcium, Caffeine, and Acetylsalicylic Acid |
| Lavender | 📋 | ✍ | ⛔ | | 35531130 | Hydroethanolic extract of Lavandula angustifolia ameliorates vincristine-induced peripheral neuropathy in rats |
| Lemon Balm Essential Oil | 📋 | ✍ | ⛔ | | 38030022 | Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models |
| Liquiritin | 📋 | | | | 36160378 | Combination of paeoniflorin and liquiritin alleviates neuropathic pain by lipid metabolism and calcium signaling coordination |
| Magnolia | 📋 | ✍ | ⛔ | | 37627513 | Honokiol-Rich Magnolia officinalis Bark Extract Attenuates Trauma-Induced Neuropathic Pain |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 28073097 | Moringa oleifera, a species with potential analgesic and anti-inflammatory activities |
| Myrrh Essential Oil | 📋 | | ⛔ | | 37783585 | The effect of back massage with frankincense and myrrh oil before the cardiac electrophysiological procedure on back pain intensity and comfort: A single-blind randomized controlled trial |
| Neroli Essential Oil | 📋 | ✍ | ⛔ | | 37469751 | The Effect of Aromatherapy with Citrus aurantium Aroma on Pain after Orthopedic Surgery: A Randomized Clinical Trial |
| Oleuropein | 📋 | | | | 33380566 | Antinociceptive effects of oleuropein in experimental models of neuropathic pain in male rats |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 20713147 | Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats |
| Pau d'Arco | 📋 | ✍ | ⛔ | | 36960315 | Safety and tolerability of Pau d' Arco ( Tabebuia avellanedae) for primary dysmenorrhea: A single-arm, open-label trial on adults ages 18-45 |
| Peppermint | 📋 | ✍ | ⛔ | | 22844342 | Effectiveness of Mentha piperita in the Treatment of Infantile Colic: A Crossover Study |
| Pineapple | 📋 | ✍ | ⛔ | | 34461191 | Ananas comosus (L) Merrill (pineapple) fruit peel extract demonstrates antimalarial, anti-nociceptive and anti-inflammatory activities in experimental models |
| Piperine | 📋 | ✍ | ⛔ | | 36274168 | Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain with no potential CNS side effects |
| Pomegranate | 📋 | | ⛔ | | 25371587 | Evaluation of the antinociceptive effect of the ethanolic extract of Punica granatum |
| Poria Mushrooms | 📋 | ✍ | | | 35398386 | Metabolites of gut microbiota fermenting Poria cocos polysaccharide alleviates chronic nonbacterial prostatitis in rats |
| Psyllium | 📋 | ✍ | ⛔ | | 27080737 | Psyllium Fiber Reduces Abdominal Pain in Children With Irritable Bowel Syndrome in a Randomized, Double-Blind Trial |
| Pterostilbene | 📋 | ✍ | ⛔ | | 36610639 | The neuroprotective effect of pterostilbene on oxaliplatin-induced peripheral neuropathy via its anti-inflammatory, anti-oxidative and anti-apoptotic effects: Comparative study with celecoxib |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 34354417 | Analgesic and anti-inflammatory effects and safety profile of Cucurbita maxima and Cucumis sativus seeds |
| Rapamycin | 📋 | ✍ | | | 37724220 | Rapamycin Augmentation of Chronic Ketamine as a Novel Treatment for Complex Regional Pain Syndrome |
| Raspberry | 📋 | ✍ | ⛔ | | 37571251 | Effects of Unripe Black Raspberry Extract Supplementation on Male Climacteric Syndrome and Voiding Dysfunction: A Pilot, Randomized, Double-Blind, Placebo-Controlled Trial |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 32730883 | Gano oil: A novel antinociceptive agent extracted from Ganoderma lucidum inhibits paw oedema and relieves pain by hypnotic and analgesic actions of fatty acid amides |
| Rosavin | 📋 | | ⛔ | | 34448466 | 5-HT 1A receptors mediate the analgesic effect of rosavin in a mouse model of oxaliplatin-induced peripheral neuropathic pain |
| Rose Essential Oil | 📋 | | | | 33234419 | The Effects of Inhalation Aromatherapy on Postoperative Abdominal Pain: A Three-Arm Randomized Controlled Clinical Trial |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 36730811 | Involvement of the NO/cGMP/KATP pathway in the antinociceptive effect of rosemary (Rosmarinus officinalis) essential oil in mice |
| Sage | 📋 | ✍ | ⛔ | | 31341489 | Salvia officinalis, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice |
| Shensong Yangxin | 📋 | ✍ | | | 36059992 | The comparative effects of oral Chinese patent medicines combined with western medicine in stable angina: A systematic review and network meta-analysis of 179 trials |
| Shogaol | 📋 | | | | 36079679 | The Effect of Ginger and Its Sub-Components on Pain |
| Soy | 📋 | ✍ | ⛔ | | 37314422 | Variation of inflammatory indexes in patients with chronic abacterial prostatitis treated with an herbal compound/extract |
| Spirulina | 📋 | ✍ | ⛔ | | 33824110 | Effects of Spirulina platensis on pain and inflammation in long Evans rats |
| Strawberry | 📋 | ✍ | ⛔ | | 34275825 | Preclinical assessment of analgesic, anti-inflammatory and antipyretic potential of Fragaria ananassa and Actinidia deliciosa fruit extract |
| Sulforaphane | 📋 | ✍ | ⛔ | | 34375671 | Sulforaphane alleviates hyperalgesia and enhances analgesic potency of morphine in rats with cancer-induced bone pain |
| Thymol | 📋 | ✍ | ⛔ | | 36339611 | The effect of thymol on acetylcholine-induced contractions of the rat ileum and uterus under ex vivo conditions |
| Trehalose | 📋 | | ⛔ | | 34578829 | Trehalose Reduces Nerve Injury Induced Nociception in Mice but Negatively Affects Alertness |
| Vitamin A | 📋 | ✍ | ⛔ | | 35215508 | Are We Sentenced to Pharmacotherapy? Promising Role of Lycopene and Vitamin A in Benign Urologic Conditions |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 31691401 | The potential role of B5: A stitch in time and switch in cytokine |
| Vitex | 📋 | ✍ | ⛔ | | 36342880 | The mechanisms underlying the role of Vitex agnus-castus in mastalgia |
| Acai Berry | 📋 | ✍ | ⛔ | | 26134625 | Antinociceptive effects of hydroalcoholic extract from Euterpe oleracea Mart. (AçaÃ) in a rodent model of acute and neuropathic pain |
| Aged Garlic | 📋 | ✍ | ⛔ | | 34302129 | Attenuation of chronic tension headache frequency and severity with daily L-arginine and aged garlic extract dietary supplementation |
| Alfalfa | 📋 | | ⛔ | | 32113847 | Analgesic and anti-inflammatory properties of hydroalcoholic extracts of Malva sylvestris, Carum carvi or Medicago sativa, and their combination in a rat model |
| Allicin | 📋 | ✍ | ⛔ | | 34071008 | Allicin Could Potentially Alleviate Oral Cancer Pain by Inhibiting "Pain Mediators" TNF-alpha, IL-8, and Endothelin |
| Amino Acids | 📋 | | | | 36079884 | Effects of Non-Essential Amino Acids on Knee Joint Conditions in Adults: A Randomised, Double-Blind, Placebo-Controlled Trial |
| Amygdalin | 📋 | ✍ | ⛔ | | 18670089 | Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats |
| Anethole | 📋 | | | | 30367337 | Neuroprotective Effect of Anethole Against Neuropathic Pain Induced by Chronic Constriction Injury of the Sciatic Nerve in Mice |
| Anthocyanins | 📋 | ✍ | ⛔ | | 15219719 | Tart Cherry Anthocyanins Suppress Inflammation-Induced Pain Behavior in Rat |
| Apple | 📋 | | ⛔ | | 25271471 | Consumption of dried apple peel powder increases joint function and range of motion |
| Apple Polyphenols | 📋 | | ⛔ | | 25271471 | Consumption of dried apple peel powder increases joint function and range of motion |
| Arjuna | 📋 | ✍ | ⛔ | | 26195913 | Evaluation of analgesic activity of Terminalia arjuna (Roxb.) Wight and Arn bark: A tribal claim |
| Artemisinin | 📋 | | | | 35721188 | Artesunate Therapy Alleviates Fracture-Associated Chronic Pain After Orthopedic Surgery by Suppressing CCL21-Dependent TREM2/DAP12 Inflammatory Signaling in Mice |
| Asiaticoside | 📋 | | | | 32294786 | Antinociceptive Activity of Asiaticoside in Mouse Models of Induced Nociception |
| Astragalin | 📋 | | | | 33505232 | Astragalin Alleviates Neuropathic Pain by Suppressing P2X4-Mediated Signaling in the Dorsal Root Ganglia of Rats |
| Avocado | 📋 | ✍ | ⛔ | | 38204814 | Non-pharmacological that most effective to reduce of primary dysmenorrhea intensity in women childbearing age: a literature review |
| Bell Pepper | 📋 | | ⛔ | | 34799309 | Analgesic and anti-inflammatory potential of four varieties of bell pepper (Capsicum annum L.) in rodents |
| Beta-Cryptoxanthin | 📋 | | | | 28110620 | Daily oral intake of β-cryptoxanthin ameliorates neuropathic pain |
| Betulinic Acid | 📋 | | | | 37574162 | Betulinic acid alleviates neuropathic pain induced by chronic constriction injury of the sciatic nerve in mice |
| Bilobalide | 📋 | | | | 23838965 | Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rats |
| Black Pepper | 📋 | ✍ | ⛔ | | 25312168 | Analgesic and anti-inflammatory activities of Piper nigrum L |
| Black Pepper Essential Oil | 📋 | | ⛔ | | 25192562 | The effectiveness of essential oils for patients with neck pain: a randomized controlled study |
| Boric Acid | 📋 | ✍ | ⛔ | | 34963081 | Boric acid improves the behavioral, electrophysiological and histological parameters of cisplatin-induced peripheral neuropathy in rats |
| Boron | 📋 | ✍ | ⛔ | | 25906949 | Effects of Boron Supplementation on the Severity and Duration of Pain in Primary Dysmenorrhea |
| Buckwheat | 📋 | | ⛔ | | 23365604 | In Vivo and In Vitro Antinociceptive Effect of Fagopyrum cymosum (Trev.) Meisn Extracts: A Possible Action by Recovering Intestinal Barrier Dysfunction |
| Burdock | 📋 | | ⛔ | | 28801728 | Arctium minus crude extract presents antinociceptive effect in a mice acute gout attack model |
| Calycosin | 📋 | | | | 37663231 | Calycosin protects against chronic prostatitis in rats via inhibition of the p38MAPK/NF-κB pathway |
| Camellia | 📋 | | ⛔ | | 35204294 | The Antinociceptive Potential of Camellia japonica Leaf Extract, (-)-Epicatechin, and Rutin against Chronic Constriction Injury-Induced Neuropathic Pain in Rats |
| Cannabidiol Oil | 📋 | ✍ | ⛔ | | 31793418 | The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities |
| CAPE | 📋 | | | | 36043777 | Caffeic Acid Phenethyl Ester (CAPE) Attenuates Paclitaxel-Induced Peripheral Neuropathy: A Mechanistic Study |
| Caraway | 📋 | | ⛔ | | 32113847 | Analgesic and anti-inflammatory properties of hydroalcoholic extracts of Malva sylvestris, Carum carvi or Medicago sativa, and their combination in a rat model |
| Caraway Essential Oil | 📋 | | ⛔ | | 29383802 | Reversal of visceral hypersensitivity in rat by Menthacarin ® , a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation |
| Cardamonin | 📋 | | | | 34208700 | Cardamonin Modulates Neuropathic Pain through the Possible Involvement of Serotonergic 5-HT1A Receptor Pathway in CCI-Induced Neuropathic Pain Mice Model |
| Carnosol | 📋 | | | | 27464306 | Anti-inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions |
| Castor Oil | 📋 | ✍ | ⛔ | | 34836854 | Antipyretic and antinociceptive potential of Ricinus communis L. and Withania somnifera L. hydroalcoholic extracts in Wistar rats: A comparative study |
| Catalpol | 📋 | | | | 36353492 | Catalpol ameliorates CFA-induced inflammatory pain by targeting spinal cord and peripheral inflammation |
| Celery | 📋 | | ⛔ | | 28160759 | Five Herbs Plus Thiamine Reduce Pain and Improve Functional Mobility in Patients With Pain: A Pilot Study |
| Clove Essential Oil | 📋 | | ⛔ | | 33167484 | Co-Application of Eugenol and QX-314 Elicits the Prolonged Blockade of Voltage-Gated Sodium Channels in Nociceptive Trigeminal Ganglion Neurons |
| Cocoa | 📋 | ✍ | ⛔ | | 37224109 | Chocolate intake and muscle pain sensation: A randomized experimental study |
| Coconut Oil | 📋 | | ⛔ | | 20645831 | Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil |
| Coffee | 📋 | ✍ | ⛔ | | 38376034 | Natural polyphenolic coffee extract administration relieves chronic nociplastic pain in a reserpine-induced fibromyalgia-like female mouse model |
| Copper | 📋 | ✍ | ⛔ | | 33568038 | Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain |
| Coptis Chinensis | 📋 | | ⛔ | | 21511022 | Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome |
| Creatine | 📋 | ✍ | ⛔ | | 29477040 | Effects of creatine supplementation on nociception in young male and female mice |
| Cucumber | 📋 | | ⛔ | | 34354417 | Analgesic and anti-inflammatory effects and safety profile of Cucurbita maxima and Cucumis sativus seeds |
| Dandelion | 📋 | ✍ | ⛔ | | 37746960 | External application of dandelion combined with borneol effectively reduced pain and facial swelling after jaw surgery |
| Diallyl Trisulfide | 📋 | | | | 32606266 | Exploring the Role and Mechanisms of Diallyl Trisulfide and Diallyl Disulfide in Chronic Constriction-Induced Neuropathic Pain in Rats |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 33241000 | Dihydromyricetin attenuates neuropathic pain via enhancing the transition from M1 to M2 phenotype polarization by potentially elevating ALDH2 activity in vitro and vivo |
| Dihydroquercetin | 📋 | | | | 35178903 | The effects of taxifolin on neuropathy related with hyperglycemia and neuropathic pain in rats: A biochemical and histopathological evaluation |
| DIM | 📋 | ✍ | ⛔ | | 37216760 | 3, 3'-diindolylmethane enhances macrophage efferocytosis and subsequently relieves visceral pain via the AhR/Nrf2/Arg-1-mediated arginine metabolism pathway |
| Echinacoside | 📋 | | | | 37812887 | Antinociceptive and neuroprotective effect of echinacoside on peripheral neuropathic pain in mice through inhibiting P2X7R/FKN/CX3CR1 pathway |
| Elderberry | 📋 | ✍ | ⛔ | | 38675372 | In Vivo Anti-Inflammatory and Antinociceptive Activities of Black Elder (Sambucus nigra L.) Fruit and Flower Extracts |
| Emu Oil | 📋 | ✍ | ⛔ | | 28691132 | Randomized phase II placebo-controlled study to evaluate the efficacy of topical pure emu oil for joint pain related to adjuvant aromatase inhibitor use in postmenopausal women with early breast cancer: JUST (Joints Under Study) |
| Eucalyptus | 📋 | ✍ | ⛔ | | 36060153 | The effect of eucalyptus inhalation on pain and the quality of life in rheumatoid arthritis |
| Fennel Essential Oil | 📋 | ✍ | ⛔ | | 12868253 | The effect of fennel (Foeniculum Vulgare) seed oil emulsion in infantile colic: a randomized, placebo-controlled study |
| Fish | 📋 | | ⛔ | | 36240701 | Fish consumption, omega-3 fatty acid intake, and risk of pain: the Seniors-ENRICA-1 cohort |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 33407941 | The comparison of the effect of flaxseed oil and vitamin E on mastalgia and nodularity of breast fibrocystic: a randomized double-blind clinical trial |
| Galangin | 📋 | | | | 38557656 | Analgesic and anti-inflammatory effects of galangin: a potential pathway to inhibit transient receptor potential vanilloid 1 receptor activation |
| Geniposide | 📋 | | | | 35699893 | Geniposide Alleviates Neuropathic Pain in CCI Rats by Inhibiting the EGFR/PI3K/AKT Pathway And Ca 2+ Channels |
| Giloy | 📋 | ✍ | ⛔ | | 38072294 | Tinospora cordifolia ameliorates paclitaxel-induced neuropathic pain in albino rats |
| Ginkgetin | 📋 | | | | 10418340 | Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves |
| Glutathione | 📋 | ✍ | ⛔ | | 35016427 | Glutathione combined with mecobalamin in the treatment of chemotherapy-induced peripheral neuropathy in multiple myeloma: a retrospective clinical study |
| Goji Berry | 📋 | ✍ | ⛔ | | 31527377 | The Use of a Combination of Vaccinium Macracarpon, Lycium barbarum L. and Probiotics (Bifiprost®) for the Prevention of Chronic Bacterial Prostatitis: A Double-Blind Randomized Study |
| Graviola | 📋 | ✍ | ⛔ | | 25133801 | Mechanisms of analgesic and anti-inflammatory properties of Annona muricata Linn. (Annonaceae) fruit extract in rodents |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 36960015 | Evaluation of the effect of green tea extract on postoperative pain management following surgical removal of impacted mandibular third molar |
| Guggulsterone | 📋 | | | | 35546904 | Z-Guggulsterone Relieves Neuropathic Pain by Inhibiting the Expression of Astrocytes and Proinflammatory Cytokines in the Spinal Dorsal Horn |
| Haritaki | 📋 | ✍ | ⛔ | | 36107372 | Analgesic effects of Terminalia chebula extract are mediated by the suppression of the protein expression of nerve growth factor and nuclear factor-κB in the brain and oxidative markers following neuropathic pain in rats |
| Hawthorn | 📋 | ✍ | ⛔ | | 34416295 | Treating unstable angina with detoxifying and blood-activating formulae: A randomized controlled trial |
| Helichrysum | 📋 | | ⛔ | | 31558010 | Pumpkin seeds, Centella asiatica, Boswellia, Helichrysum, acetate vitamin E, Melaleuca alternifolia and hyaluronic acid phytocomplex monotherapy effects in patients with chronic pelvic pain syndrome |
| Honokiol | 📋 | | | | 37627513 | Honokiol-Rich Magnolia officinalis Bark Extract Attenuates Trauma-Induced Neuropathic Pain |
| Hypericin | 📋 | | | | 28216196 | Hypericum Perforatum (St John's Wort) Beyond Depression: A Therapeutic Perspective for Pain Conditions |
| Icaritin | 📋 | | | | 35202753 | Trifluoro-icaritin alleviates chronic inflammatory pain through α7nAChR-mediated suppression of HMGB1/NF-κB signaling in the spinal cord of rats |
| Jasmine | 📋 | | ⛔ | | 25479154 | Anti-inflammatory, analgesic and anti-pyretic activities of standardized root extract of Jasminum sambac |
| Jujube | 📋 | | ⛔ | | 34354595 | Analgesic Effect of Ziziphus abyssinica Involves Inhibition of Inflammatory Mediators and Modulation of K ATP Channels, Opioidergic and Nitrergic Pathways |
| Kaempferol | 📋 | ✍ | ⛔ | | 35234314 | Kaempferol exerts a neuroprotective effect to reduce neuropathic pain through TLR4/NF-ĸB signaling pathway |
| Krill Oil | 📋 | ✍ | ⛔ | | 35880828 | Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial |
| Kudzu Root | 📋 | ✍ | ⛔ | | 37629284 | Effects of Plant-Based Extract Mixture on Alcohol Metabolism and Hangover Improvement in Humans: A Randomized, Double-Blind, Paralleled, Placebo-Controlled Clinical Trial |
| L-Lysine | 📋 | ✍ | ⛔ | | 35696944 | Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study |
| Lemon Verbena | 📋 | | ⛔ | | 22087615 | A randomized, double-blinded, placebo-controlled study of the effect of a combination of lemon verbena extract and fish oil omega-3 fatty acid on joint management |
| Licochalcones | 📋 | | | | 37419692 | Licochalcone Mediates the Pain Relief by Targeting the Voltage-Gated Sodium Channel |
| Loquat | 📋 | ✍ | ⛔ | | 21182921 | Anti-inflammatory and antinociceptive properties of the leaves of Eriobotrya japonica |
| Lotus | 📋 | | ⛔ | | 33728272 | Anti-nociceptive, anti-inflammatory and possible mechanism of anti-nociceptive action of methanol leaf extract of Nymphaea lotus Linn (Nymphaeceae) |
| Lupeol | 📋 | | | | 33945040 | Analgesic and anti-inflammatory potential of Lupeol isolated from Indian traditional medicinal plant Crateva adansonii screened through in vivo and in silico approaches |
| Lutein | 📋 | ✍ | ⛔ | | 33910832 | The Effect of Lutein on Ischemia-reperfusion-induced Vasculitic Neuropathic Pain and Neuropathy in Rats |
| Malva Sylvestris | 📋 | | ⛔ | | 32113847 | Analgesic and anti-inflammatory properties of hydroalcoholic extracts of Malva sylvestris, Carum carvi or Medicago sativa, and their combination in a rat model |
| Manganese | 📋 | ✍ | ⛔ | | 33568038 | Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain |
| Mangosteen | 📋 | ✍ | ⛔ | | 32592535 | Investigating the ameliorative effect of alpha-mangostin on development and existing pain in a rat model of neuropathic pain |
| Marigold | 📋 | ✍ | ⛔ | | 28679180 | A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III |
| Mint | 📋 | | ⛔ | | 34916937 | Anti-Hyperalgesic Properties of Menthol and Pulegone |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 26872020 | Galectin-3 Inhibition Is Associated with Neuropathic Pain Attenuation after Peripheral Nerve Injury |
| Morin | 📋 | | | | 31011938 | Morin Alleviates Vincristine-Induced Neuropathic Pain via Nerve protective Effect and Inhibition of NF-κB Pathway in Rats |
| Morusin | 📋 | | | | 10817216 | Antinociceptive properties of morusin, a prenylflavonoid isolated from Morus nigra root bark |
| Myrtle | 📋 | ✍ | ⛔ | | 22196507 | Antinociceptive, anti-inflammatory effects and acute toxicity of aqueous and ethanolic extracts of Myrtus communis L. Aerial parts in mice |
| Neem | 📋 | ✍ | | | 36382046 | Effects of Azadirachta indica on neuropathic pain induced by chronic constriction injury to sciatic nerve of Wistar rat |
| Neferine | 📋 | | | | 32882253 | Neferine alleviates P2X3 receptor in rat dorsal root ganglia mediated neuropathic pain |
| Neohesperidin | 📋 | | | | 36331667 | Neohesperidin Alleviates the Neuropathic Pain Behavior of Rats by Downregulating the P2X4 Receptor |
| Nicotinamide | 📋 | ✍ | ⛔ | | 31388880 | Thiamine, riboflavin, and nicotinamide inhibit paclitaxel-induced allodynia by reducing TNF-α and CXCL-1 in dorsal root ganglia and thalamus and activating ATP-sensitive potassium channels |
| Nobiletin | 📋 | ✍ | | | 35976195 | Analgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice |
| Noni | 📋 | | ⛔ | | 36727425 | Noni fruit extract ameliorates alcohol-induced hangover symptoms by reducing the concentrations of alcohol and acetaldehyde in a Sprague Dawley rat model and a human intervention study |
| Nutmeg | 📋 | ✍ | ⛔ | | 30312165 | A randomized comparative study of herbal decoction of Cassia fistula Linn pod's pericarp and Myristica fragrans Houtt arils vs. mefenamic acid in spasmodic dysmenorrhoea |
| Olive Polyphenols | 📋 | | | | 33008039 | The Inhibitory Effect of Extra Virgin Olive Oil and Its Active Compound Oleocanthal on Prostaglandin-Induced Uterine Hypercontraction and Pain-Ex Vivo and In Vivo Study |
| Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 34526307 | Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial |
| Omega-9 Fatty Acids | 📋 | | | | 28495596 | The role of Omega-3 and Omega-9 fatty acids for the treatment of neuropathic pain after neurotrauma |
| Oolong Tea | 📋 | | ⛔ | | 30962237 | Association of tea drinking and dysmenorrhoea among reproductive-age women in Shanghai, China (2013-2015): a cross-sectional study |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 33234419 | The Effects of Inhalation Aromatherapy on Postoperative Abdominal Pain: A Three-Arm Randomized Controlled Clinical Trial |
| Oregano Essential Oil | 📋 | ✍ | ⛔ | | 35354677 | Antinociceptive, anti-inflammatory, and cytotoxic properties of Origanum vulgare essential oil, rich with β-caryophyllene and β-caryophyllene oxide |
| Papain | 📋 | ✍ | ⛔ | | 32122870 | Efficiency of proteolytic enzymes in treating lumbar spine osteoarthritis (low back pain) patients and its effects on liver and kidney enzymes |
| Papaya | 📋 | ✍ | ⛔ | | 33433362 | Carica papaya leaf extract inhibits prostatitis-associated prostatic hyperplasia via the TRAF6/TAK1/MEK/NF-κB pathway |
| Parsley | 📋 | | ⛔ | | 38338356 | Exploring the Therapeutic Efficacy of Parsley ( Petroselinum crispum Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis |
| Parthenolide | 📋 | | | | 37306715 | Parthenolide as a potential analgesic in the treatment of paclitaxel-induced neuropathic pain: the rat modeling |
| Patchouli | 📋 | ✍ | ⛔ | | 28795389 | Anti-nociceptive effect of patchouli alcohol: Involving attenuation of cyclooxygenase 2 and modulation of mu-opioid receptor |
| Perilla | 📋 | ✍ | | | 36998613 | Efficacy of Perilla frutescens (L.) Britton var. frutescens extract on mild knee joint pain: A randomized controlled trial |
| Polydatin | 📋 | ✍ | | | 36281234 | Using Network Pharmacology and Animal Experiment to Investigate the Therapeutic Mechanisms of Polydatin against Vincristine-Induced Neuropathic Pain |
| Pregnenolone | 📋 | ✍ | ⛔ | | 32119096 | Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial |
| Proanthocyanidins | 📋 | | | | 35185451 | Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model |
| Progesterone | 📋 | ✍ | ⛔ | | 35924434 | Therapeutic potential of progesterone in spinal cord injury-induced neuropathic pain: At the crossroads between neuroinflammation and N-methyl-D-aspartate receptor |
| PUFA | 📋 | | | | 37743908 | Causal association of polyunsaturated fatty acids with chronic pain: a two-sample Mendelian randomization study |
| Pyridoxal-5-Phosphate | 📋 | ✍ | ⛔ | | 24593783 | Pyridoxal-5'-phosphate (MC-1), a vitamin B6 derivative, inhibits expressed P2X receptors |
| Rhodiola | 📋 | ✍ | ⛔ | | 38505080 | Investigating the multitarget pharmacological mechanism of Rhodiola wallichiana var. cholaensis acting on angina pectoris using combined network pharmacology and molecular docking |
| Rose | 📋 | | | | 29765566 | Efficacy of combination of Viola odorata, Rosa damascena and Coriandrum sativum in prevention of migraine attacks: a randomized, double blind, placebo-controlled clinical trial |
| Rutin | 📋 | ✍ | ⛔ | | 36512286 | Rutin ameliorates inflammatory pain by inhibiting P2X7 receptor in mast cells |
| Salidroside | 📋 | | | | 34626306 | Salidroside Alleviates Chronic Constriction Injury-Induced Neuropathic Pain and Inhibits of TXNIP/NLRP3 Pathway |
| Salvianolic Acid | 📋 | | | | 35500448 | Salvianolic acid B alleviates comorbid pain in depression induced by chronic restraint stress through inhibiting GABAergic neuron excitation via an ERK-CREB-BDNF axis-dependent mechanism |
| Schisandrins | 📋 | | | | 38431110 | Schisandrin B from Schisandra chinensis alleviated pain via glycine receptors, Nav1.7 channels and Cav2.2 channels |
| Scutellarin | 📋 | | | | 32447519 | Revealing the Common Mechanisms of Scutellarin in Angina Pectoris and Ischemic Stroke Treatment via a Network Pharmacology Approach |
| Senolytics | 📋 | | | | 35426375 | Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence |
| Sesame | 📋 | ✍ | ⛔ | | 37373663 | Effect of Turmeric-Boswellia-Sesame Formulation in Menstrual Cramp Pain Associated with Primary Dysmenorrhea-A Double-Blind, Randomized, Placebo-Controlled Study |
| Shilajit | 📋 | ✍ | ⛔ | | 25830280 | Mumijo attenuates chemically induced inflammatory pain in mice |
| Sirtuin Activators | 📋 | | | | 35396903 | SIRT1: A promising therapeutic target for chronic pain |
| Skullcap | 📋 | ✍ | ⛔ | | 33505504 | The Effectiveness of Scutellaria baicalensis on Migraine: Implications from Clinical Use and Experimental Proof |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 35906640 | Effect of soy isoflavones supplementation on migraine characteristics, mental status and calcitonin gene-related peptide (CGRP) levels in women with migraine: results of randomised controlled trial |
| Spearmint | 📋 | | ⛔ | | 16868824 | The Efficacy of an Herbal Medicine, Carmint, on the Relief of Abdominal Pain and Bloating in Patients With Irritable Bowel Syndrome: A Pilot Study |
| Spearmint Essential Oil | 📋 | ✍ | ⛔ | | 28107842 | Mentha spicata as natural analgesia for treatment of pain in osteoarthritis patients |
| Spermidine | 📋 | | | | 36799067 | Spermidine reduced neuropathic pain in chronic constriction injury-induced peripheral neuropathy in rats |
| St. Johns Wort Oil | 📋 | | ⛔ | | 31673442 | Effective Medicinal Plants in the Treatment of the Cyclic Mastalgia (Breast Pain): A Review |
| Sugarcane | 📋 | | ⛔ | | 35422173 | Flavonoids and fractions from Saccharum officinarum L. juice: antinociceptive agents and molecular docking evaluations with µ-opioid receptor |
| Tea | 📋 | | | | 35677547 | Six Types of Tea Reduce Acute Alcoholism in Mice by Enhancing Ethanol Metabolism, Suppressing Oxidative Stress and Inflammation |
| Telmisartan | 📋 | | ⛔ | | 37175678 | Telmisartan Is a Promising Agent for Managing Neuropathic Pain and Delaying Opioid Analgesic Tolerance in Rats |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 26832325 | Antiinflammatory and analgesic effects of Eurycoma longifolia extracts |
| Turnip | 📋 | | ⛔ | | 30560075 | Analgesic Effect of Valerian Root and Turnip Extracts |
| Urolithins | 📋 | | | | 37464536 | Urolithin A alleviates neuropathic pain and activates mitophagy |
| Vitamin B7 | 📋 | ✍ | ⛔ | | 34221058 | Effect of biotin supplementation on neuropathic pain induced by chronic constriction of the sciatic nerve in the rat |
| Vitamin B8 | 📋 | ✍ | ⛔ | | 27127407 | A Randomized Pilot Study of Inositol in Association with Betaine and Boswellia in the Management of Mastalgia and Benign Breast Lump in Premenopausal Women |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 35203045 | Vitamin K2 as a potential therapeutic candidate for the prevention of muscle cramps in hemodialysis patients: A prospective multicenter, randomized, controlled, crossover pilot trial |
| Vitamins | 📋 | | | | 37374091 | Vitamin Effects in Primary Dysmenorrhea |
| Wenxin Keli | 📋 | ✍ | ⛔ | | 27881911 | Systematic review and meta-analysis of randomized controlled trials on Wenxin keli |
| Wheat | 📋 | | ⛔ | | 34804895 | The effect of Triticum sativum (wheat) germ on postpartum pain: A double-blind clinical trial |
| Whey Protein | 📋 | ✍ | ⛔ | | 34858171 | Resistance Exercise and Whey Protein Supplementation Reduce Mechanical Allodynia and Spinal Microglia Activation After Acute Muscle Trauma in Rats |
| Wine | 📋 | | ⛔ | | 37571406 | Benefits of the Light Consumption of Red Wine in Pain, Tender Points, and Anxiety in Women with Fibromyalgia: A Pilot Study |
| Withanolides | 📋 | | | | 33424246 | Withametelin: a biologically active withanolide in cancer, inflammation, pain and depression |
| Wogonin | 📋 | ✍ | ⛔ | | 36860203 | Wogonin, a Bioactive Ingredient from Huangqi Guizhi Formula, Alleviates Discogenic Low Back Pain via Suppressing the Overexpressed NGF in Intervertebral Discs |
| Wormwood | 📋 | ✍ | ⛔ | | 37629284 | Effects of Plant-Based Extract Mixture on Alcohol Metabolism and Hangover Improvement in Humans: A Randomized, Double-Blind, Paralleled, Placebo-Controlled Clinical Trial |
| Yiang Yiang Essential Oil | 📋 | | ⛔ | | 35551977 | Ylang-ylang (Cananga odorata (Lam.) Hook. f. & Thomson) essential oil reduced neuropathic-pain and associated anxiety symptoms in mice |
